• Dissemination of results in progress

Optima Trial

The Optima trial is a large-scale multisite interventional study.


Prevention and treatment of opioid use disorder (OUD) has become an urgent public health priority in Canada.

Although methadone has long been the standard of care for the treatment of opioid use disorder in Canada, there is growing consensus that the superior safety profile of buprenorphine/naloxone, as well as other comparative advantages, supports its use as a first-line therapy for opioid use disorder. The OPTIMA trial aims to evaluate these two treatment options within a Canadian practice‐based framework, generating evidence that is directly relevant to a recognized national priority in public health.


Evaluate and compare the effectiveness of two different models of care for the treatment of prescription opioid use disorders (methadone and buprenorphine/naloxone) to improve patient care.

In Quebec

Randomized participants (QC)
Participants completed the study protocol (QC)

Steering committee

  • Cameron Wild, PhD
    Cameron Wild, PhD Prairies NPI
    • Evan Wood, MD, PhD
      Evan Wood, MD, PhD British Columbia NPI
      • Julie Bruneau, MD, MSc
        Julie Bruneau, MD, MSc Quebec-Atlantic NPI
        • Jurgen Rehm, PhD
          Jurgen Rehm, PhD Ontario NPI

          Regional principal investigators

          • Bernard Le Foll, MD, PhD
            Bernard Le Foll, MD, PhD Ontario Node
            • Didier Jutras-Aswad, M.D., M.Sc. Quebec-Atlantic Node - Lead RPI
              • Eugenia Socias, MD
                Eugenia Socias, MD British Columbia Node
                • Keith Ahamad, MD
                  Keith Ahamad, MD British Columbia Node
                  • Ronald Lim, MD
                    Ronald Lim, MD Prairies Node

                    National Team

                    • Aïssata Sako
                      Aïssata Sako Program Director
                      • Jill Fikowski, MPH
                        Jill Fikowski, MPH National Research Coordinator

                        Clinical research coordinators

                        • Amel Zertal, MSc
                          Amel Zertal, MSc Clinical Research Coordinator - Quebec-Atlantic Node
                          • Angela Wallace
                            Angela Wallace Clinical Research Coordinator - Prairies Node
                            • Benita Okocha, MSc
                              Benita Okocha, MSc Clinical research coordinator - BC node
                              • Leanne Trick, MSc, PhD
                                Leanne Trick, MSc, PhD Clinical Research Coordinator - Ontario Node

                                For more information

                                For information about the Optima study, please contact your regional node:

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